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Neonatal TSH Elisa kit

TSH-Neo ELISA is intended for the quantitative determination of Thyroid Stimulating Hormone (TSH) in newborn blood specimens dried on filter paper and used as a screening test for congenital hypothyroidism in babies. TSH is a glycoprotein with MM ca. 30 kDa which is secreted by the anterior lobe  of the pituitarty gland. TSH molecule is combined from two non-covalently bound polypeptide chains: alpha-chain and beta-chain. Specificity and biological activity of TSH is caused by its beta-chain. Congenital hypothyroidism is a hereditary pathology expressed in altered thyroid function and found with prevalence ca 1:3500 – 1:4000. Congenital hypothyroidism is characterized by a decreased secretion of thyroid hormons – T3 and T4, this in turn upregulating TSH secretion and leading to elevated TSH levels  in blood. Screening of newborns with congenital hypothyroidism is based on cut-off TSH value.  If TSH value obtained is higher that the cut-off, it indicates a possible pathological state and requires additional laboratory investigations. To confirm the diagnosis, quantification of TSH and T4 in serum is required. 

Kit is CE certified and IVD use