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Anti-Gliadin IgA ELISA KIT for IVD use

Celiac disease (CD) or gluten-sensitive entheropathy is a chronic disease characterized by impaired intestinal absorption due to mucosal lesions. The exact ethiology of CD is unknown but it is clearly shown that gliadin – the alcohol soluble fraction of wheat gluten – is the toxic agent. High concentrations of antigliadin antibodies (AGA) found in blood, saliva and intestinal secretions are characteristic for untreated celiac patients. These antibodies gradually disappear after gluten exclusion from the patient’s diet. AGA testing is a simple and inexpensive method to efficiently select candidates for mucosal biopsy of the duodenal-jejunal junction, the latter method being essential for the confirmation of the diagnosis of CD. Early detection of AGA in high risk populations would contribute to prevent the insidious consequences of chronic malabsorption. Individuals at risk include short-stature children, unexplained anemia, unexplained hypocalciemia or osteomalacia, delayed puberty, insulin-dependent diabetes mellitus, autoimmune thyroiditis and selective IgA deficiency. It is well established that IgA-AGA are more specific than IgG-AGA. Nevertheless, combined IgG/IgA screening might be more effective since there is an unexplained but clear association between CD and selective IgA deficiency. In treated celiac patients without this deficiency IgA-AGA is the test of choice for monitoring diet compliance. Serum IgA-AGA level responds very quickly to the admission of gluten-free diet (levels drop below the cut-off level within two to six months) while IgG-AGA may take more than one year to become negative; breaking the diet causes more prompt elevation of IgA-AGA compared to IgG-AGA. Herpetiform dermatitis is a disease entity strongly associated to gluten-sensitive enteropathy, and AGA serology is not capable to distinguish between these two diseases. Separately, there are well reported clinical conditions showing positive IgG-AGA and, rarely, IgA-AGA nonrelated to histologically proven CD, eg all kind of malapsortion syndromes, including Crohn's disease, ulcerative colitis, galactosidase deficiency, postinfection malapsorption etc. The patients with rheumatoid arthritis, Sjogren syndrome, systemic sclerosis and other connective tissue diseases show abnormally high prevalence of moderately elevated gliadin IgA and IgG. These findings may be considered as non-relevant to GI pathology; however, gliadin free diet may be implemented for their treatment.

Kit is CE Certified and IVD use..total assay time is 75 minutes...Ready to use kit components with control..kindly ask for more details..               .