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tT3 Elisa kit

3,5,3’-triiodothyronine (T3) exert regulatory influences on growth, differentiation, cellular metabolism and development of skeletal and organ systems. T4 and T3 in blood are found both in free and bound form – mostly, they are bound to thyroxin binding globulin (TBG). Only free forms of T3 and T4 exert hormonal activity also their percentage is very low – 0.3% for T3 and 0.03% for T4. The concentration of T3 is much less than that of T4 but its metabolic activity is about 3 times greater. About 80% of T3 is produced in peripheral tissues by deiodination of T4, and only 20% is secreted by thyroid gland. That is why in hypothyroid patients T3 level may for a long time remain on the lower limit of the normal range, because its loss may be compensated by enhanced conversion of T4 into T3. Determination of T3 level is most useful in T3-hyperthyroidism because 5-10% of such patients do not show significant changes in T4 level while concentration of T3 is highly elevated. Elevated T3 levels are seen in early thyroid hypofunction, after intake of estrogens, oral contraceptives, heroin, methadone, during pregnancy. Decreased concentrations of T3 are found in initial stage of hyperthyroidism, acute and subacute thyroiditis, after intake of androgens, dexamethasone, salycilates.

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