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tT4 ELISA kit

Thyroid hormones thyroxin (T4) and 3,5,3’-triiodothyronine (T3) exert regulatory influences on growth, differentiation, cellular metabolism and development of skeletal and organ systems. T4 and T3 in blood are found both in free and bound form – mostly, they are bound to thyroxin binding globulin (TBG). Only free forms of T3 and T4 exert hormonal activity also their percentage is very low – 0.3% for T3 and 0.03% for T4. The concentration of T4 is generally accepted as an index of thyroid function which provide enough information to differentiate between hyper-, hypo- and euthyroidism. Elevation of total T4 is found in hyperthyroidism, in patients with tumours of pituitary gland, in subjects with elevated TBG level (pregnancy, acute or chronic active hepatitis, estrogen-secreting tumours or estrogen intake, hereditary elevation of TBG), in patients taking oral contraceptives, heroin, methadone, thyroid preparations, TSH, thyroliberin. Low total T4 is found in hypothyroidism, in patients with panhypopituitarism, in subjects with low TBG level (acromegaly, nephritic syndrome, hypoproteinemia, chronic liver diseases, androgen-secreting tumours, hereditary reduction), in patients taking aminosalicylic and acetylsalicylic acids, cholestyramine, reserpine, potassium iodide, triiodothyronine. 

Kits are available IVD use,CE certified...for more details please write to us