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Human FGF21 Elisa kit for IVD use in serum&Plasma

This “sandwich” ELISA kit is intended for the quantitative determination of human intact FGF-21 level in EDTA-plasma or serum. The test is useful as an aid in diagnosis of primary musclemanifesting respiratory chain deficiencies, nonalcoholic fatty liver disease and other conditions related to type 2 diabetes, gestational diabetes and obesity.

Fibroblast Growth Factor 21 (FGF-21) belongs to the FGF-19 subfamily, which includes FGF-19, FGF-21 and FGF-23. The FGF19 family members are potent endocrine hormones in the regulation of a diverse physiological homeostasis. The intact FGF-21 is a small protein comprising 181 amino acids. Administration of recombinant FGF-21 lowered plasma glucose and insulin levels, reduced hepatic and circulating triglycerides and cholesterol levels, and improved insulin sensitivity, energy expenditure, hepatic steatosis and obesity in a range of insulinresistant animal models. The physiological functions of FGF-21 are relied on the intact molecular structure and amino acid sequence in its N-terminal and C-terminal region. An N-terminal truncated FGF21 (7-181) is a potent inhibitor that competitively inhibits the biological activity of intact FGF-21 (1-181). Therefore, it is important to measure the circulation intact FGF-21 level in the assessment of the physiological and pathophysiological condition. An assay that determines the fragment of the FGF-21 might overestimate the biological activity of the protein in test sample.  Circulation FGF-21 is a biomarker and its levels are increased in patients with nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, gestational diabetes and obesity. An increase of circulating FGF-21 is also found in patients with Cushing’s syndrome, patients with lipodystrophy induced by HIV-1 and patients with chronic renal disease or end-stage renal disease. 

Kit is CE certified,IVD USE, With low n high controls...kindly ask for More details..